Additionally, the overexpression of PBK failed to promote ovarian cancer cell autophagy with mTOR or ERK1/2 knockdown, and the restoration of mTOR or ERK1/2 expression could partly rescue the autophagy blocked by knockdown of mTOR or ERK1/2 in A2780 and SKOV3 cells (Supplementary Fig. S8). The gene discussed is MAPK3; the disease is ovarian cancer.