RRM2 and familial pancreatic carcinoma: Hence, to study the potential interplay between miRNA and RRM2 and to further explore the opportunity of utilizing miRNAs for pancreatic cancer therapeutics, we sought to determine the direct impact of eight RRM2-related miRNAs, predicted by TargetscanSites, picTarSites, RNA22Sites, PITASites or miRandaSites.org algorithms, on acquired gemcitabine resistance.