Subgroup analyses were performed in different ages (<60 vs ≥60), gender (female vs male), history of smoking and drinking (Yes vs No), BMI (normal vs overweight or obesity), ESR (≥20 vs <20) and CRP (ESR ≥ 8 vs <8), and Kellgren–Lawrence grading (I/II vs III vs IV). This evidence concerns the gene CRP and Obesity.