Subgroup analyses were performed in different ages (<60 vs ≥60), gender (female vs male), history of smoking and drinking (Yes vs No), BMI (normal vs overweight or obesity), ESR (≥20 vs <20) and CRP (ESR ≥ 8 vs <8), and Kellgren–Lawrence grading (I/II vs III vs IV). The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.