In order to define the role played by HAI-2 in matriptase regulation in neoplastic B-cells, the global expression status of matriptase in relation to HAI-1 and HAI-2 at the mRNA level in haematological cancer cells versus epithelial/carcinoma cells was analysed in the 945 human cancer cell lines collected in the Cancer Cell Line Encyclopaedia (CCLE) database. The gene discussed is SPINT1; the disease is cancer.