These included the established BRCA1/2 genes, a handful of additional genes that have been indicated previously as prospective PCa candidates (ATM, CHEK2, GEN1, MSH2, and RNASEL), and several novel genes for which limited substantive evidence for a role in PCa predisposition has been presented to date (BLM, CDC25C, ERCC3, LIG4, MSH5, NEIL2, NHEJ1, PARP2, POLD1, POLE, POLM, RECQL4, and TDP1). This evidence concerns the gene CHEK2 and posterior cortical atrophy.