POLE and posterior cortical atrophy: These included the established BRCA1/2 genes, a handful of additional genes that have been indicated previously as prospective PCa candidates (ATM, CHEK2, GEN1, MSH2, and RNASEL), and several novel genes for which limited substantive evidence for a role in PCa predisposition has been presented to date (BLM, CDC25C, ERCC3, LIG4, MSH5, NEIL2, NHEJ1, PARP2, POLD1, POLE, POLM, RECQL4, and TDP1).