These included the established BRCA1/2 genes, a handful of additional genes that have been indicated previously as prospective PCa candidates (ATM, CHEK2, GEN1, MSH2, and RNASEL), and several novel genes for which limited substantive evidence for a role in PCa predisposition has been presented to date (BLM, CDC25C, ERCC3, LIG4, MSH5, NEIL2, NHEJ1, PARP2, POLD1, POLE, POLM, RECQL4, and TDP1). Here, MSH2 is linked to posterior cortical atrophy.