Moreover, experimental infection in sockeye salmon (Oncorhynchus nerka) with PRV-1 fail to induce IFN related genes [38], whereas PRV-1 infection successfully trigger IFN related immune response modulating the susceptibility of Atlantic salmon to subsequent challenge with Infectious haematopoietic necrosis virus—IHNV or Salmonid alphavirus—SAV [35, 39, 40]. The gene discussed is IFNA1; the disease is infection.