JAK2 and cancer: We trained our model on JAK2-inhibitor Ruxolitinib response (IC50: Min screening conc: 0.0205, Max screening conc: 5.24, Geometric mean: 53.2) using 982 tissue-specific cancer cell lines from the Genomics of Drug Sensitivity in Cancer (GDSC) database (www.cancerRxgene.org) [22] (Fig. 2a).