Interestingly, Arf1 is further overexpressed in highly invasive breast cancer cells compared with non-invasive breast cancer cells, and its expression levels are strongly associated with poor survival of breast cancer patients, which may be also attributed to the involvement of the EGFR-Arf1 complex in the progression of cell invasion and metastasis [15, 25, 39]. Here, ARF1 is linked to breast cancer.