Continuous activation of BCR in ABC-type DLBCL leads to the phosphorylation and activation of regulatory and adaptor proteins, such as spleen tyrosine kinase (SYK), Bruton’s tyrosine kinase (BTK), and protein kinase C-β (PKCβ), especially in ABC-type DLBCL [2, 6–8]. Here, BTK is linked to diffuse large B-cell lymphoma.