In the TCGA dataset, 115 of 152 patient tumours were CTR positive (~ 76%) by our criteria and similarly to the IVY-GAP dataset, there was also no relationship between CTR expression and survivorship (Fig. 5d); this result that was borne out when we plotted expression against survivorship for the TCGA dataset (Additional file 1: Figure S2D). This evidence concerns the gene CALCR and neoplasm.