Others [28] have reported a change in GBM cell line proliferation in response to CTR stimulation and this has also been reported for a breast cancer cell line [50, 51], we therefore assessed whether activation (using both hCT and sCT) or blockade (using the antagonist sCT(8–32)) would alter metabolism in the SB2b cell line. This evidence concerns the gene SCT and glioblastoma.