In contrast, but consistent with public databases, all primary tumours had detectable message for CALCRL and all RAMPs with one cell line losing detectable CALCRL expression along with 3 xenografts, one xenograft losing RAMP2 and 7 cell lines and 5 xenografts having no detectable RAMP3 (Fig. 1). The gene discussed is RAMP3; the disease is neoplasm.