Real-time RT-PCR results reveal that expression of kiss1r is present at elevated levels (~ 7-fold higher) in COS compared to normal osteogenic progenitor cells (Fig. 1f), which accompanied by absent kiss1 expression in the latter cells (Fig. 1b), suggests a potential aberration of the kisspeptin peptide/receptor system in this type of cancer (Fig. 1d, e). This evidence concerns the gene KISS1R and cancer.