To investigate whether SOX17 sensitizes ESCC cells to anti-cancer treatments by transcriptionally down-regulating DNA damage-responsive and repair-related genes, we examined the effect of SOX17 overexpression on mRNA expression of these genes in KYSE510-R-SOX17 cells treated with cisplatin, radiation, or CCRT. This evidence concerns the gene SOX17 and esophageal squamous cell carcinoma.