SOX17 and esophageal squamous cell carcinoma: Our previous study established the six-CpG panel of DNA methylation biomarkers including IFNGR2, KCNK4, NOTCH4, NPY, PAX6 and SOX17 for CCRT response prediction in pre-treatment endoscopic biopsies from ESCC patients with known CCRT responses during follow-up [28].