Previous researches have shown that mutations in ANK1 (ankyrin 1), SPTB (spectrin, beta, erythrocytic), SPTA1 (spectrin alpha, erythrocytic 1), SLC4A1 (solute carrier family 4, member 1, or band 3), and EPB42 (erythrocyte membrane protein band 4.2) are associated with HS [5]. Here, EPB42 is linked to histiocytic sarcoma.