Remarkably, in this study, we observed that mice carrying the 129P1 donor allele from the distal portion of the QTL (64.4–82.1 Mb) conferred a positive effect on weight phenotype without affecting diabetes-related phenotypes, such as IPGTT profile, area under the curve during IPGTT, and insulin response in znt7-KO mice. The gene discussed is SLC30A7; the disease is diabetes mellitus.