Critically, we further show that a smaller gene network (NGENES = 56) supporting microglia-mediated innate immunity (as identified in a recent exome-wide study (Sims et al., 2017)) also show evidence for shared genetic overlap with HV, with a similar effect size to that of all AD risk alleles across the genome (excluding APOE and MHC regions). Here, APOE is linked to Alzheimer disease.