GSTM1 and Iron deficiency anemia: In our study, with this dosage iron diet feed, the hemoglobin (Hb) content was maintained at normal levels at 10 week, once the diet contains less than 20 mg/kg iron, the mice began to displayed low levels of Hb, erythrocyte mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and were diagnosed as having iron-deficiency anemia at 10 weeks (Supplementary Fig. 6).