PADI4 and infection: In their model of infection‐induced lung injury (instillation of a high dose of methicillin‐resistant Staphylococcus aureus), NETs were formed in the airspaces and also in the microvasculature, leading to poor survival of the animals due to overt lung injury.65 On the other hand, when mice were unable to produce NETs in response to the infection (PAD4−/−), lung injury was indeed reduced; however, bacterial clearance was significantly impaired.