Monocytes can differentiate into Mφs or DCs after entering tissue (discussed below), but they are also able to enter tissues such as skin and draining lymph nodes without differentiation.35 Adoptively transferred monocytes up‐regulate MHCII and CD11c after migrating into lymph nodes, which depends on CCR2 and CD62L.35, 82 Although monocytes appear to have clear Ag‐presenting functions during homeostasis and infection,14 their role in presentation of tumor‐derived Ags remains less explored. This evidence concerns the gene CCR2 and neoplasm.