While CCR2 signaling is the key chemokine receptor for recruitment of classical monocytes, CX3CR1 plays a key role in migration of nonclassical monocytes.8 Recruitment of nonclassical monocytes to primary colorectal tumors and metastatic lung tumors is dependent on CX3CR13, 97; however, whether CX3CR1 is protumoral or antitumoral remains unclear. The gene discussed is CX3CR1; the disease is colorectal neoplasm.