CD47 and central nervous system cancer: CD47 expression is prognostic for poor clinical outcome in a number of different cancers, including ovarian cancer, glioma, glioblastoma, and non‐small cell lung cancer.67, 68 Evasion of phagocytosis is likely also critical during metastasis to distal sites, as CD47 expression correlates with the presence of lymph node and distal metastases in non‐small cell lung cancer patients.68 Whether CD47/SIRPα interactions play a role in monocyte‐mediated regulation of metastasis (discussed below) also requires further investigation.