The average expression of lysosomal genes was significantly increased in the asymptomatic NPC1 KO brain and liver (Figure 1—figure supplement 1A), and increased further with the onset of the disease in NPC1 KO brain and liver (Figure 1—figure supplement 1A), in agreement with the expected increase in the expression of lysosomal genes in lysosomal storage diseases. The gene discussed is NPC1; the disease is lysosomal storage disease.