Among these genes, the mitochondrial ribosomal protein family participated in energy production and mitochondrial disease (23), the chaperonin family containing TCP1 genes was implicated in cell cycle progression (24), and cyclin B1 (CCNB1) as a cell cycle regulated protein was involved in cell proliferation and tumor growth (25). The gene discussed is CCNB1; the disease is inborn mitochondrial metabolism disorder.