EGFR and chordoma: Erlotinib was the most commonly used anti-EGFR agent and was analyzed in 10 studies (16 patients) for the treatment of chordoma (13, 17, 22, 32, 33, 35, 38, 40–42), including one clinical trials (22), one retrospective case study (17) and eight case reports (13, 17, 22, 32, 33, 35, 38, 40–42).