In this study, we describe the comparison of RNA-sequencing (RNA-seq) data from head and neck squamous cell carcinoma, and later from uterine corpus endometrial carcinoma, that are mutant or wild type for CASP8. We report distinctive molecular features of mutant-CASP8 HNSCs and UCECs that this comparison revealed. Here, CASP8 is linked to uterine corpus endometrial carcinoma.