Consistent with the GSEA results, CASP8-MT cases showed significantly higher infiltration of CD8+ T cells, neutrophils, and dendritic cells as compared to CASP8-WT cases (p-values < 0.0005), suggesting that the immune response to the tumor in WT and MT cases was different (Figs. 3A–3C). Here, CASP8 is linked to neoplasm.