Here, we report a distinct class of carcinomas that have mutated CASP8. Using bioinformatics approaches to mine the TCGA data, we identified high expression of immune response-related genes (listed in Table S7) combined with high infiltration of CD8+ T cells and dendritic cells as a prominent shared immune signature in CASP8-MT carcinomas. The gene discussed is CASP8; the disease is carcinoma.