CASP8 and neoplasm: Since CASP8 is an important mediator of the extrinsic apoptotic pathway, CASP8-MT tumors may have greater resistance to Fas- or DR5- mediated cell death pathways, which are typically employed by CD8+ T cells and Natural Killer cells to target infected/tumor cells  (Li et al., 2014; Rooney et al., 2015).