Other pathologic features linked to effects of excessive GH may be observed, such as vertebral deformities and abnormal calcium levels, increased risk of cardiovascular disease, respiratory comorbidities, and glucose intolerance.1,38,39 Hypersecretion of GH leads to elevated concentrations of circulating IGF1 in acromegalic patients, and these two hormones may have different metabolic features and target tissue responses.40 This evidence concerns the gene GH1 and cardiovascular disorder.