More recently Wilkinson et al. demonstrated that fusion of GHBP to a GHR antagonist protein similar to B2036 significantly reduced IGF1 by 14% after a single subcutaneous injection in rabbits and may be useful for treating acromegaly.128 Introduction of a W104A mutation in the fused GHBP prevented intra- and inter-molecular binding. The gene discussed is IGF1; the disease is acromegaly.