IGF1 and hyperinsulinemic hypoglycemia, familial, 4: Disruption of GH and IGF1 signaling extends lifespan, enhances insulin sensitivity, decreases DNA and protein oxidation in the liver, reduces cancer incidence and may reduce age-related inflammation.20,104–108 GHR dysfunction clearly protects individuals with Laron Syndrome against aging-related diseases such as cancer and diabetes, but it is unclear whether GH/IGF1 deficiency increases human lifespan, although a handful of studies have indicated that attenuated GH/IGF1 function is associated with human longevity.109,110