These differences are of importance, since the particular surface molecule that is targeted appears to influence the type of immune response that is elicited.11–14 For example, targeting of antigen to chemokine receptors 1, 3, and 5 induced predominantly a T-cell response that could mediate broad protection against influenza.13 In order to see if the response could even more stringently be polarized to T-cell immunity, we targeted antigen to chemokine XC receptor 1 (Xcr1), exclusively expressed by type 1 cDCs. Here, XCR1 is linked to influenza.