Vaccination with an adenovirus-based vaccine delayed tumor growth in 30–40% of mice, while vaccination in combination with anti-CD40 and anti-CTLA-4 antibodies induced complete responses in all mice.147 In another study, mice treated with anti-CTLA-4 and an OX40 agonist antibody plus a DC vaccine targeting HER2 had significantly improved survival in a mammary carcinoma model.148. This evidence concerns the gene TNFRSF4 and neoplasm.