BCL2 and glioblastoma: When we overexpressed HRK in Bcl-2 and/or Bcl-xL and GFP-expressing GBM cells, we observed that Bcl-2 and/or Bcl-xL overexpression inhibited HRK- induced apoptosis and led to the recovery of cell death in LN18 (Fig. 2d), U87MG (Fig. 2f, h), and U373 (Fig. 2e, g), but not in A172 cells (Fig. 2c).