We validated Nampt’s involvement in arthritis using a CIA mouse model7,8 in wild-type and Nampt heterozygous knockdown DBA/1J mice, and we investigated further the pathways underlying Nampt’s mechanism in arthritis through loss-of-function and gain-of-function studies experiments in mouse bone marrow-derived macrophages (BMM) and RNA sequencing (RNA-seq) of CIA mouse tissue. This evidence concerns the gene NAMPT and arthritic joint disease.