We leveraged high-density genotyping data linked to EHR-derived phenotypes from the electronic MEdical Records and GEnomics (eMERGE) Network31,32 to conduct a PheWAS to test the association of variants in PCSK9, APOB, and LDLR with non-lipid phenotypes, including diabetes, neurocognitive disorders, and cataracts. The gene discussed is PCSK9; the disease is cataract.