The second of these studies51 examined only a single PCSK9 variant, rs11591147, in 337,536 individuals of predominantly European ancestry in the UK Biobank and demonstrated it to be associated with hyperlipidemia and coronary heart disease, which is similar to our results which trended toward association with ischemic heart disease but not with type 2 diabetes. The gene discussed is PCSK9; the disease is hyperlipidemia.