Of note, a recent GWAS report described that only a very small fraction of LDL-C lowering genetic variants (only 5 out of 113 variants from 90 distinct loci) were associated with type 2 diabetes.48 None of these were in PCSK9, APOB, or LDLR. However, a lack of pleiotropic effects in a subset of variants does not exclude the possibility of pleiotropic effects for other variants in the studied genes or in other ethnic backgrounds. This evidence concerns the gene PCSK9 and type 2 diabetes mellitus.