APOB and diabetes mellitus: This includes the PCSK9 variant rs11591147 and the LDLR variant rs6511720 for which prior studies have reported borderline significant associations with increased risk of diabetes.11,34 In the NHGRI-EBI GWAS catalog, no associations of PCSK9, APOB, or LDLR variants with diabetes, neurocognitive disorders, or cataract have been reported.