Despite the high inter- and intra-tumor heterogeneity, we identified that stem cell quiescence-associated genes ALDH1L1, HOPX, WNT5A and SOX9 were commonly hypomethylated across all the samples post NAC treatment, which holds the potential to be developed as therapeutic targets or biomarkers for chemoresistance. The gene discussed is WNT5A; the disease is neoplasm.