In contrast of present study, based on our previous findings in 2014, we did not find any correlation between rs1047840 SNP and risk of CRC by PCR-RFLP analysis (11) as well as Zienolddiny et al. that have presented no association between Exo1 K589E polymorphism and the risk of non-small cell lung cancer in Caucasian Norwegian (19). This evidence concerns the gene EXO1 and colorectal carcinoma.