The present study was undertaken to evaluate the most common mutation of codon 72 of p53 protein in reticular oral lichen planus in comparison to oral SCC as an oral mucosa malignant lesion, in which the mutation of the tumor suppressor gene of p53 has been commonly identified.1 An inflammatory and hyperplastic benign lesion such as an epulis fissuratum was used as a negative control. Here, TP53 is linked to oral lichen planus.