Mutation of p53 gene is the most important genetic change in human cancers13 and some studies have shown some degrees of mutation in p53 gene in OLP patients, especially in women.5 In addition, some studies have shown apoptosis in lichen planus due to the expression of p53 protein.14 On the other hand, another study compared the molecular characteristics of lichen planus and dysplastic and reactive lesions and normal oral mucosa and did not fully support the premalignant nature of oral lichen planus.1 The gene discussed is TP53; the disease is oral lichen planus.