Out of the 63 genes, mutations were found in ATM, CDKN1B, CREBBP, CYLD, KMT2B, KRAS, MAX, TP53, and TRAF3. Mutations were highly clonal across all driver genes, with a median cancer cell fraction of 0.91, suggesting that mutations occurred early in disease pathogenesis. This evidence concerns the gene TRAF3 and cancer.