A strong association between CXCR4 mRNA expression level and 5-year OS was observed for the R-CHOP-treated DLBCL patient cohort (n=233) but not for the CHOP-treated cohort (n=181), with high CXCR4 expression characterizing poor outcome (Figure 1A-1B). This evidence concerns the gene CXCR4 and diffuse large B-cell lymphoma.