SETD2 and nonpapillary renal cell carcinoma: Combined, these data demonstrate that the capacity of SETD2 deficient ccRCC-derived cell lines to form spheroids (3-D) and to migrate (2-D) is significantly hindered by PI3Kβ-specific inhibitors, which we observed is closely replicated when these cells are treated with the Pan-PI3K inhibitor BKM120.