Ma et al. demonstrated that VDBP, 1α-hydroxylase, 24-hydroxylase, and vitamin D receptor were expressed on the placenta [32], and Cleal et al. showed that maternal 25(OH)D and VDBP concentrations may mediate the regulation of amino acid transfer to the fetus [33], suggesting that dysregulation of VDBP as well as vitamin D could be a risk factor in the pregnancy outcome (i.e., preeclampsia, preterm birth, and gestational diabetes) [34]. This evidence concerns the gene VDR and gestational diabetes.