In order to compare the IL-10−/− chronic colitis model to a model of acute colitis, the above confirmed biomarkers were trialled in a DSS mouse model of acute colitis; PZP and PRDX2, previously found to be increased in colitic IL-10−/− mice, were not altered in mice treated with DSS, suggesting that these markers are specific to a chronic inflammatory state. Here, IL10 is linked to Chronic colitis.