CLEC16A is a well-established autoimmune disorder susceptibility gene and has been associated with several autoimmune diseases, including type-1 diabetes (1–5), multiple sclerosis (6), primary adrenal insufficiency (7), Crohn's disease (8), primary biliary cirrhosis (9), juvenile idiopathic arthritis (10), rheumatoid arthritis (10), and alopecia areata (11), suggesting that CLEC16A could be a master regulator of aberrant autoimmune responses. The gene discussed is CLEC16A; the disease is primary biliary cholangitis.