Of note, although LAMP2A is cleaved by lysosomal cathepsin A (24) and lysosomal protease inhibitors increase the amount of lysosomal membrane-localized LAMP2A in cystinosis (14), it is not yet clear whether this mechanism of LAMP2A upregulation may have direct implications in proximal tubule cell function. The gene discussed is CTSA; the disease is cystinosis.