CXCL8 and cystic fibrosis: With progressing age, persistent exacerbations primarily caused by Pseudomonas aeruginosa (Pa) and the ensuing IL-8 mediated persistent neutrophilic inflammation are the hallmark of clinical CF lung disease and a major contributor to irreversible lung damage as well as CF-related fatalities (Bodas and Vij, 2010; Ferrari et al., 2017; Bodas et al., 2018a).