Recent studies have highlighted the potential of Thymosin α-1 (Tα1), a thymic peptide with broad immune-modulatory properties, in correcting the basic CF-defect, i.e., the restoration of misfolded F508del-CFTR to the PM (Romani et al., 2017; Garaci, 2018; Rubin, 2018; Stincardini et al., 2018). This evidence concerns the gene TAAR1 and cystic fibrosis.