The PI3K/AKT/mTOR signaling pathway is altered in several disease states such as cancer (Conciatori et al., 2018; Guri et al., 2018), immune system-related diseases (Guri et al., 2018; Jung et al., 2018), idiopathic pulmonary fibrosis (IPF) (Lawrence and Nho, 2018), COPD (Houssaini et al., 2018; Wang et al., 2018) and lymphangioleiomyomatosis (LAM) (Gao et al., 2018). This evidence concerns the gene AKT1 and lymphangioleiomyomatosis.