People with these mutations on both the copies of their Cftr gene demonstrate the classical manifestations of CF lung disease, such as a thick and sticky mucus, mucin hypersecretion, elevated inflammatory-oxidative stress and/or persistent bacterial infections, which collectively result in severe airway obstruction (Bodas and Vij, 2010; Bodas et al., 2018a). This evidence concerns the gene CFTR and lung disorder.