There is a plethora of evidence in recent studies that a partial (in chronic obstructive pulmonary disease, COPD) (Cantin, 2016; Bodas et al., 2017; Vij, 2017; Shi et al., 2018) or complete loss (in CF) (Luciani et al., 2010; Cantin, 2016) of functional CFTR protein from the PM leads to reactive oxygen species (ROS)-mediated autophagy impairment. This evidence concerns the gene CFTR and chronic obstructive pulmonary disease.