CFTR and cystic fibrosis: Although huge strides have been made in the development of novel “breakthrough” drug combinations such as Orkambi®, Symdeko® etc., to rectify the core CF-defect, their widespread therapeutic advantage has been restricted due to somewhat low efficacy in maintaining sustained CFTR-activation as well as controlling other components of CF lung disease such as chronic inflammatory-oxidative stress responses and exacerbations.