For instance, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A regulate CLDN4 and influence tumor formation and metastasis via a ceRNA-mediated regulatory network in GC [30], while HOTTIP promotes small cell lung cancer via a HOTTIP/miR-574-5p/EZH1-associated ceRNA network [31]. This evidence concerns the gene HOTTIP and small cell lung carcinoma.