NLRP3 and colitis: There are conflicting reports about the role of NLRP3 in intestinal inflammation.Others have demonstrated that NLRP3 plays an important role in the induction ofcolitis in DSS-treated mice and a spontaneous model of colonic inflammation,11,14 while others have observed a protective effect for NLRP3.41 In the present study, MCC950 was shown to have efficacy in attenuating DSSintestinal inflammation, but only in the highly susceptibleNod2−/− mice.