RB1 and hepatocellular carcinoma: RB depletion in hepatoma cells resulted in a compromised immunological response to multiple stimuli.32 In bladder cancer, RB under expression was predictive of poor response to bacille Calmette‐Guerin (BCG) therapy in concert with interferon‐alpha (IFNα) therapy, providing further evidence that RB plays a role in mediating immune response.33, 34 In cervical cancer, human papilloma virus (HPV) oncoprotein E7 is known to bind to RB and cause its inactivation.