For example, miR‐876‐5p inhibits EMT and tumour metastasis of lung cancer by repressing bone morphogenetic protein 4 (BMP‐4).14 MiR‐876‐5p suppresses tumour growth and metastasis of ESCC by targeting Melanoma Antigen Genes‐A (MAGE‐A) family expression.15 Furthermore, miR‐876‐5p restrains HCC progression via suppression of BCL6 corepressor like 1 (BCORL1) and DNA methyltransferase 3α (DNMT3A).16, 17 Thus, the mechanism involved in the functional role of miR‐876‐5p in OS needs to be investigated. This evidence concerns the gene DNMT3A and lung cancer.