DNMT3A and esophageal squamous cell carcinoma: For example, miR‐876‐5p inhibits EMT and tumour metastasis of lung cancer by repressing bone morphogenetic protein 4 (BMP‐4).14 MiR‐876‐5p suppresses tumour growth and metastasis of ESCC by targeting Melanoma Antigen Genes‐A (MAGE‐A) family expression.15 Furthermore, miR‐876‐5p restrains HCC progression via suppression of BCL6 corepressor like 1 (BCORL1) and DNA methyltransferase 3α (DNMT3A).16, 17 Thus, the mechanism involved in the functional role of miR‐876‐5p in OS needs to be investigated.