Clinically, circulating klotho deficiency has been proposed to be a biomarker of chronic kidney disease and vascular age‐related diseases (Hu et al., 2014), and soluble and vascular klotho inversely correlates with inflammatory markers in human atherosclerosis (Martín‐Núñez et al., 2017). This evidence concerns the gene KL and hyperinsulinemic hypoglycemia, familial, 4.