MAPT and semantic dementia: Despite the association between tau conformers, localization of tau lesions, and clinical phenotypes, the symptomatic manifestations and progression of a single tauopathy can vary.4, 5, 6 The microtubule‐associated protein tau (MAPT) haplotypes may account for the clinicopathological characteristics of PSP7 and frontotemporal dementia (FTD).4, 8 Moreover, a number of MAPT mutations cause familial tauopathies, which are termed frontotemporal dementia and parkinsonism linked to chromosome 17 MAPT (FTDP‐17/MAPT).