The fibrosis-related markers (TGFB1, ACTA2, SNAIL, and TWIST) showed no differences between HPS2-AOs and cHPS2-AOs (Figure 2C), consistent with the findings of the animal study in that the Ap3b1 mutant (Pearl) mice did not develop PF spontaneously (Young et al., 2007). The gene discussed is ACTA2; the disease is pemphigus foliaceus.