UCP1 and obesity due to melanocortin 4 receptor deficiency: Moreover, Sestrin2 regulated the PERK-c/EBPβ pathway by mediating mTORCI [41, 42], and inhibited the ROS-mediated p38 MAPK activation and interfered the expression of uncoupling protein 1 (Ucp1), subsequently resulting in the decrease of heat production and the increase of adipose tissue, which led to obesity [43, 44].