ENO2 and neoplasm: Neuroendocrine (NE)-like PCa is identified by increased staining of neuroendocrine differentiation (NED) markers, e.g. neuron-specific enolase (NSE), chromogranin A (CgA), and synaptophysin (Syn), and is believed to originate from trans-differentiated tumor cells that give rise to CRPC following ADT [6, 7].