Consistent with this scenario, it was reported that osteoblasts precursors secrete significant higher levels of IL-6, IL-10, BAFF, HGF, and VEGF, suggesting that suppression of osteoblast differentiation enhances tumor growth by creating a tumor permissive microenvironment [55, 92, 94] (Fig. 3). The gene discussed is HGF; the disease is neoplasm.