Gene-expression analysis after silencing of β-catenin [34] and treatment with PKF115-584 [35] and CGK012 [38] showed downregulation of the Wnt target genes CCND1 (encoding cyclin D1) and MYC, which are known to play a key role in the pathogenesis of MM [4, 42, 43]. This evidence concerns the gene CCND1 and Miyoshi myopathy.