In ~50% of MGUS and MM patients, recurrent translocations involving the immunoglobulin heavy chain (IgH) locus are found, which drive the expression of juxtaposed genes, including Cyclin D1 (CCND1,11q13), FGF3/MMSET (4p16.3), Cyclin D3 (CCND3, 6p21), MAFC (16q23), and MAFB (20q11). This evidence concerns the gene CCND1 and Miyoshi myopathy.