Transient transfection of AKT1DD(308D473D), or AKT2DD initiated phosphorylation of cellular STING and TICAM2 even in absence of infection, which was inhibited by dominant-negative AKT1AAA(K179A/T308A/S473A) or AKT2AAA (Fig. 3i). This evidence concerns the gene STING1 and infection.